How to Set Up a Small Business Accounting Expense Ledger …

A general ledger (GL) contains five sections: assets, liabilities, owner?s equity, revenue, and expenses. Each of these sections is a separate accounting ledger or book, so the GL is what is referred to when talking about your company?s books. Each ledger book contains several accounts, so your expense ledger will contain these accounts: rent, telephone, electric utilities, office supplies, and all the other individual categories of expenses you might have in your business.

Instructions

Organizing Your Ledger System

1. Examine your bank statements and compile a list of regular monthly expenses, quarterly and annual expenses, and another list of variable expenses such as office supplies, marketing, entertainment, and travel. Use these lists in setting up your chart of accounts.

2. Establish your chart of accounts. The different ledgers in your COA are traditionally numbered as follows: 1000-1999 assets, 2000-2999 liabilities, 3000-3999 owner?s equity, 4000-4999 revenue, 5000-5999 cost of goods sold, 6000-6999 marketing & intangibles expense, 7000-7999 other revenues, 8000-8999 administrative, travel, personnel & miscellaneous business expenses.

3. The marketing & intangibles expense ledger may include 6000-6099 general expenses, 6100 advertising, 6200 financial fees, 6300 charitable donations, 6400 depreciation, 6500 employee benefits, 6600 taxes, 6700 insurance. Each category will be further divided into numbered subcategories such as officers? and directors? insurance, errors & omissions insurance, liability insurance, vehicle insurance, and any other insurance you carry.

4. The administrative, travel, personnel & miscellaneous business expense ledger may include subcategories such as 8100 rent, 8200 electric utilities, 8300 Internet, 8400 telephone, 8500 legal, accounting & consultants, 8600 salaries & wages, 8650 payroll taxes, 8700 office supplies, 8800 repair & maintenance, and other expenses of doing business.

5. Take one of your current bills, a utility bill. Mark your ledger account number on it. Look under the administrative, travel, personnel & miscellaneous category of your COA and find the 8200 electric utilities category. If you separate out utilities in your warehouse from those for the office and those for the showroom, you should create account numbers for each of those categories so your warehouse utility bill may be 8220, the office 8230 and the showroom 8240.

Source: http://simpleaccounting.info/set-small-business-accounting-expense-ledger/

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Identifying acute myeloid leukemia gene mutations may indicate risk, best treatment

Identifying acute myeloid leukemia gene mutations may indicate risk, best treatment

Saturday, March 24, 2012

An international group of researchers, including those from Moffitt Cancer Center in Tampa, Fla., have published a paper in the March 14 issue of the New England Journal of Medicine reviewing the results of a study that analyzed mutations in 18 genes of 398 patients who had acute myeloid leukemia (AML). They found that several mutated genes predicted improved outcomes when patients with certain gene mutations were given high-dose induction chemotherapy. Their findings suggest that mutational profiling could potentially be used for both risk stratification and also in helping health care providers make therapeutic decisions for some AML patients.

“Previous studies have found that AML is a highly heterogenic disorder,” said study co-author Hugo F. Fernandez, a senior member at Moffitt and associate chief of Moffitt’s Blood and Marrow Transplantation Division. “Moreover, recent studies have revealed that a number of genetic mutations in AML patients might have prognostic value. The question of the presence of these gene mutations altering outcomes based on current therapy had not been answered to date.”

Their paper cites a clinical trial carried out by the Eastern Cooperative Oncology Group (ECOG) in which dose-intensified chemotherapy improved outcomes in two age sets of AML patients. Based on these findings, the research team hypothesized that carrying out mutational analysis of all known molecular alterations occurring in more than 5 percent of patients with AML might allow for the identification of distinct, molecularly defined subgroups of patients who might benefit from dose-intensified chemotherapy.

The laboratory research team subsequently performed a mutational analysis on diagnostic samples from 398 patients enrolled in the ECOG clinical trial they cited and used patients’ frozen sample cells for extraction and profiling. The researchers validated the results of this latter group of 104 patients.

“We found that intensification of the dose of anthracycline significantly improved outcomes and overall survival in patients with mutations in DNMT3A, NPM1 or MLL translocations,” said Fernandez. “This finding suggests that mutational profiling could be used to determine which AML patients will benefit from dose-intensive induction therapy.”

“Most importantly,” said Fernandez, “this study demonstrates how integrated mutational profiling of samples from a clinical trial cohort can advance understanding of the biologic characteristics of AML.”

###

H. Lee Moffitt Cancer Center & Research Institute: http://www.moffitt.usf.edu

Thanks to H. Lee Moffitt Cancer Center & Research Institute for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/118695/Identifying_acute_myeloid_leukemia_gene_mutations_may_indicate_risk__best_treatment

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Reader photos: Southern California Moments, Day 83

About L.A. Now

L.A. Now is the Los Angeles Times? breaking news section for Southern California. It is produced by more than 80 reporters and editors in The Times? Metro section, reporting from the paper?s downtown Los Angeles headquarters as well as bureaus in Costa Mesa, Long Beach, San Diego, San Francisco, Sacramento, Riverside, Ventura and West Los Angeles.

Have a story tip for L.A. Now?

Can I call someone with news?

Yes. The city desk number is (213) 237-7847.

Source: http://feeds.latimes.com/~r/lanowblog/~3/kGPLXMOelVo/reader-photos-southern-california-moments-day-83.html

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A secret hero in Germany

Someone has been leaving envelopes of $13,000 in various locations like a church and soup kitchen in the town of Braunschweig, Germany.

? A local, slice-of-life story from a Monitor correspondent.

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?The Hospice Am Hohen Tore in Braunschweig is an unusually cheerful place these days.

?Maybe it?s a kind of Robin Hood,? says Michael Knobel, the manager. ?Or someone with no family who wants to give something back to society ? that would be the romantic interpretation.?

Mr. Knobel is engaged in a game that all of Braunschweig is currently playing: Guess who? ?Who? has for several weeks been placing envelopes containing ?10,000 (more than $13,000) each at various places around town. A church, a kindergarten, and a soup kitchen have all received the unmarked envelopes filled with 500-euro notes. In all, ?200,000, or close to $260,000, has been given away.

In some instances, a clipping from Braunschweiger Zeitung, the local newspaper, referring to the recipient accompanies the money. ?Of course, this is great for us as well,? says Henning Noske, who edits the local news at Braunschweiger Zeitung. ?People love mystery, secrecy, fairy tales. They love to read about it, and we can give it to them.? The fact that he now receives dozens of e-mails with requests by organizations and individuals to be reported on is a small price to pay, he adds.

Donating is less established in Germany than it is in the United States. People pay high taxes and in return expect the state to spend money on welfare, culture, and other causes.

Get daily or weekly updates from?CSMonitor.com?delivered to your inbox.?Sign up today.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/Khz2GzLwnK8/A-secret-hero-in-Germany

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Supreme Court Allows Lawsuit in E.P.A. Wetlands Case

[unable to retrieve full-text content]An Idaho couple may seek judicial review of Clean Water Act restrictions on their property, the Supreme Court ruled.

Source: http://feeds.nytimes.com/click.phdo?i=001b6b04378283312dfce9f853808b3f

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How to Trade China’s Slowing Growth

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The red-hot Chinese economy is slowing, and the government is pushing back. This strategist has a way to play the tension.

China’s economy is slowing so much, the country has essentially ordered its citizens to ‘shop till you drop’ by designating National Consumption Month. Gina Sanchez, economic director of equity and asset allocation at Roubini Global Economics, is skeptical.?

Sanchez expects a push for consumers to spend to simply accelerate consumption rather than increase it overall. In addition, she told CNBC’s Melissa Lee, “we think that falling property prices are going to impact the wealthy and that’s going to impact National Shopping Month.” Still, she does anticipate a certain inflationary impact from the spending push – and of course inflation tends to be positive for a currency.

Rebecca Patterson, chief markets strategist for J.P. Morgan Asset Management, Institutional, agrees, and points out that as far as China is concerned, “you can play it through a lot of other liquid markets.”

Patterson has looked at several currencies for patterns parallel to China’s, and she has found a winner: the Australian dollar, [AUD=X? Loading...? ? ? () ? ] at 88 percent correlation.

She thinks that the Chinese will force economic growth higher, but she also believes that in the very near term, the Australian dollar could weaken further over concerns about China’s economic outlook. Patterson wants to buy the Aussie against the dollar around a technical support level at 1.0100, setting a stop at 0.9875 and a target of 1.0600.

“If you hold this position over time, you make money on the interest rate differentials as well,” she she points out.

You can watch the discussion on this video.

————–

CURRENCY FUTURES

Tune In: CNBC’s “Money in Motion Currency Trading” airs on Fridays at 5:30pm and repeats on Saturdays at 7pm.

Learn more: The essential vocabulary for currency trading is on Key Currency Terms. Top currency strategies are broken down for you in Currency Class.

Talk back: Tell us what you want to hear about – email us at .

? 2012 CNBC.com

Source: http://www.cnbc.com/id/46840627?__source=RSS*tag*&par=RSS

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rumblestrip: @awilsonphoto so you have a new iPad, just not the NEW iPad?

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@awilsonphoto so you have a new iPad, just not the NEW iPad?

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Windows Cell phone 8.0 And it is Capabilities | American Electronics …

Top ten touchscreen handsets available in the UK mobile market place are Iphone 3GS 32GB, Motorola Droid Palm Pre, Apple iPhone 3GS 16GB, BlackBerry Storm two, Motorola Cliq, Samsung Moment, HTC Droid, Eris Palm Pixi and Samsung Omnia. Now in all leading on the internet and onsite mobile retailers you can find lots of hot touch screen mobile phone deals. Handyortung

Recycling your telephone advantages environmental surroundings in terms of decreasing emissions, lessening the use of scarce natural resources and reducing the quantity of waste that results in unsightly landfills.

To make the internet individual, ArrayComm had also used its adaptive antenna technology and come up with i-BURST personal Broadband system, which delivers affordable high speed mobile access to the internet for the consumer. Handyortung kostenlos ohne Anmeldung

The Hosted Communications platform and the mobile platform are collocated and, for optimum choice and resilience, connectivity is to many alternative networks. The service utilises resilient IP connections into carrier networks to deliver voice services.

Soundminer is an extra malware which calls for approval access your handset?s microphone stand, underneath the guise associated having a handful of innocent support. After that it information telephone calls and can be applied a structure evaluation coder good at ?predicting? your most likely information of your voice make contact with. Valuable phone calls with automatic standard bank systems for example, are usually noted and provided any on the web hackers ?value rating?. This is applicable for that files talked and also enter into the phone, through the keyboard.

Telephone To require your cellular marketing and advertising for the subsequent degree, advertise your mobile telephone assortment. It sounds mundane to promote a telephone range once the mobile telephone companies are chock full of spot conscious services and directions when needed. But, tend not to overlook most cell gadgets are phones. Get your cellular phone selection out inside the open. Area it prominently around the residence web page inside your optimized web site. Just a single click of that cellphone number gives them straightforward accessibility with your business. The previous recommendations of telephone marketing and advertising also make use of to telephone marketing and advertising. The phone get in touch with from a earnings man or woman for the duration of dinner time is One in the quickest methods to drop sales along with a client. Time your advertising and marketing messages for mid-morning to early-afternoon. Tend not to deliver messages in the middle with the night or while dining time. Only add telephone numbers from buyers picking out to collect messages to construct your mobile phone advertising and marketing database thoroughly. In case you add telephone figures of customers who?ve not elected to get telephone marketing and advertising messages, you will be most likely to see a excessive quantity of grievances and requests being deleted out of your checklist. Cellphone Though it truly is vital becoming brief in cellphone communications, do not incorporate TXT shorthand with your messages to customers. Regardless of its total acceptance, TXT abbreviations are unprofessional. You might come across that buyers who acknowledge shorthand are counterbalanced by an equal quantity that take into account offense or are switched off by it. Stay away from the whole balanced exercise and stay with suitable language. Do not overlook branding. In your rush to begin mobile marketing and advertising, you may overlook that your telephone marketing and advertising efforts call for to become integrated into your higher promoting endeavours along with your manufacturer. Expanding your model recognition will help convey you plenty more customers, so don?t forget about your model when emailing attainable consumers by means of cellphone. QR codes really are a sensible method to provide interactive articles together with your clients. These QR codes are a great method to improve and entice your customers by supplying coupons and special discounts. QR codes are easy to scan that has a smartphone, as well as less challenging to use. By creating use of this resource you?ll be able to interact along with your buyers even though you may have their attention. These are merely a handful of of the ways that you are able to flip the omnipresence of good devices in your benefit as being a enterprise owner. Getting a cellphone-pleasant marketing and marketing and advertising strategy could be the identical at present as an web site advertising method was ten decades previously. Phone promoting is a burgeoning topic. In the event you get into it now, you?ll be able to commence reaping the rewards that a lot far more rapidly. Handyortung ohne Anmeldung

For a lot of years now, the very best UK cell phone businesses such as Orange, Vodafone, T-Mobile, O2 and Virgin Mobiles have provided free gifts with mobile phone contracts as a good marketing approach. A totally free mobile telephone gift, particularly some thing of the high perceived value can be the ultimate clincher when if comes to attracting and subsequently signing up a brand new customer.

Nokia e63 mobile is the low cost version of e71. It has launched in Nov, 2008 in India. Nokia e63 mobile is a superb handset through the Nokia. But when we evaluation the whole mobile marketplace there aren?t any. of mobile brands exist and offering the exact same capabilities like Nokia e63 mobile at very reasonable price tag. Even the looks act like this mobile phone. Will individuals choose the Nokia? Well yes obviously the good quality and sturdiness which Nokia is donations are much much better than the every other mobile telephone brand. As far as the price is concern, educated men and women believe in purchasing the mobile of trustworthy brand and from resource even its tiny pricey from any other brand and resource. It is challenging for just about any mobile brand to compete with king of all the mobile phones Nokia.

Source: http://www.zai-amelex.com/windows-cell-phone-8-0-and-it-is-capabilities-4350

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Romney to look for laughs, and votes, on Leno show

Republican presidential candidate, former Massachusetts Gov. Mitt Romney addresses an audience during a campaign stop at an American Legion post in Arbutus, Md., Wednesday, March 21, 2012. (AP Photo/Steven Senne)

Republican presidential candidate, former Massachusetts Gov. Mitt Romney addresses an audience during a campaign stop at an American Legion post in Arbutus, Md., Wednesday, March 21, 2012. (AP Photo/Steven Senne)

(AP) ? Mitt Romney has been a target of Jay Leno jokes, and now he’ll get the chance to give the late-night comedian a few jabs in return.

NBC announced Thursday that the Republican presidential candidate will be the lead guest on the “Tonight Show” on Tuesday. It’s the former Massachusetts governor’s first visit to Leno’s stage during the 2012 presidential season.

Over the years, Leno has riffed about the candidate’s wealth ? Romney is a multimillionaire ? and poked him on his restrained ? some say stiff ? demeanor.

Romney has been a Leno guest three times in the past, but this will be his first appearance since 2010.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2012-03-22-Leno-Romney/id-9d6f2b00e6084c399d058c5bec172d80

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